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Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes

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dc.authorscopusid10040320700
dc.authorscopusid34168278000
dc.authorscopusid6602283105
dc.authorscopusid24829334600
dc.authorscopusid8852671900
dc.authorscopusid55664812000
dc.contributor.authorYildirim, T.
dc.contributor.authorŞenkuytu, E.
dc.contributor.authorErgene, E.
dc.contributor.authorBilgin, K.
dc.contributor.authorUludaǧ, Y.
dc.contributor.authorÇiftçi, G.Y.
dc.date.accessioned2020-06-21T13:07:03Z
dc.date.available2020-06-21T13:07:03Z
dc.date.issued2018
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Yildirim] Tuba, Department of Biology, Amasya Üniversitesi, Amasya, Turkey; [Şenkuytu] Elif, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkey; [Ergene] Emel, Department of Biology, Anadolu Üniversitesi, Eskisehir, Eskisehir, Turkey; [Bilgin] Kemal, Department of Medical Services and Techniques, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Uludaǧ] Yıldız Bozkurt, Bioelectronic Devices and Systems Group, Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, Kavaklidere, Ankara, Turkey; [Çiftçi] Gönül Yenilmez, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Kocaeli, Turkeyen_US
dc.description.abstractIn this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, 1H, 31P NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.identifier.doi10.1002/slct.201801766
dc.identifier.endpage9939en_US
dc.identifier.issn2365-6549
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-85053410365
dc.identifier.scopusqualityQ3
dc.identifier.startpage9933en_US
dc.identifier.urihttps://doi.org/10.1002/slct.201801766
dc.identifier.volume3en_US
dc.identifier.wosWOS:000444538800024
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherWiley-Blackwell info@wiley.comen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.journalChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Activityen_US
dc.subjectCyclophosphazeneen_US
dc.subjectDNA Bindingen_US
dc.subjectFluorenylideneen_US
dc.subjectPhosphazeneen_US
dc.titleBiological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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