Evaluation of Nano Sized Mg@BTC Metal Organic Framework as a Drug Carrier: A Long Term Experimental and Predictive Theoretical Study

Abstract

Metal Organic Frameworks (MOFs) have found wide applications as a drug carrier in nanotherapeutics because of adjustable pore-sizes, controllable structural properties, large surface area and high pore volume. In this work, nanosized Mg@BTC is synthesized by electrochemical method and used as a new drug carrier for ibuprofen. The ibuprofen (IB) is loaded to the Mg@BTC 1:1 ratio with the amount of %99.8. The release of ibuprofen from nanocarrier has been observed experimentally for long term. After 100.5 hours, the release ratio yields 36 %. The ibuprofen has been tested at 40 ± 0.5 °C. System showed a rapid release after 100 hours, the release ratio yields 72.29 %. The release profile of IB loaded Mg@BTC is tested by using model depended mathematical models to get observation and prediction of the release. Zero Order Model, First Order Model, Higuchi Model, Peppas Model and Hixon Model functions are fitted to the release profiles. Watson’s U Squared Method is used to test the fit strength of the models. Observation from the release profiles, it is seemed Peppas Model yields the best results. Also, thermodynamic analysis has been studied. © 2021 MIM Research Group. All rights reserved.