Synthesis, Characterization, and Antimicrobial Activity of Copper(II) Complexes with N,N′-Propanediyl and N,N′-Ethanediyl

Abstract

Copper(II) complexes of new aryldisulfonamides (L <inf>1</inf> = N,N′-bis[(2-methylphenyl)sulfonyl]ethylenediamine) and L <inf>2</inf> = N,N′-propanediyl-bis-benzenesulfonamide with 1,10-phenanthroline have been synthesized and characterized by using elemental analyses, FT-IR, LCMS, conductivity, and magnetic susceptibility techniques. The structures of [Cu(phen) <inf>2</inf> ]L <inf>1</inf> (1) and [CuL <inf>2</inf> (phen) <inf>2</inf> ] (2) compounds have been determined. Complex (1) has also been characterized by single crystal X-ray diffraction. The complex (1) crystallizes in the triclinic system, space group P1, with cell constants a = 12.9353(8) Å, b = 13.8543(9) Å, c = 14.4513(10) Å, α = 103.593(5), β = 113.713(5), γ = 106.104(5), and Z = 1. The antibacterial activities of synthesized compounds were studied against Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, and B. cereus and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, and Yersinia enterocolitica by microdilution (as MICs in μg/mL) and disk diffusion (as diameter zone in mm) method. The biological activity screening showed that (1) has more activity than (2) against the tested bacteria. © 2012 Springer Science+Business Media, LLC.