Psychiatric Disorders and Symptoms Severity in Pre-School Children with Cow's Milk Allergy

Abstract

Background: Psychiatric disorders are seen frequently in atopic diseases. The present study aims to evaluate the frequency of psychiatric disorders and the severity of psychiatric symptoms in pre-school children with cow's milk allergy. Methods: The parents of the pre-school children with cow's milk allergy were interviewed in person and asked to fill out the Early Childhood Inventory-4 form. Results: The cow's milk allergy group included 40 children (27 male, 13 female) with mean age, 44.5 +/- 14.7 months, and the control group included 41 children (25 male, 16 female) with mean age, 47.6 +/- 15.2 months. It was established that 65% of the group with cow's milk allergy received at least one psychiatric diagnosis, while 36.6% of the control group received at least one psychiatric diagnosis, with a statistically significant difference (p = 0.02). Within the psychiatric disorders, attention deficit hyperactivity disorders (odds ratio: 4.9, 95% CI: 1.472-16.856, p = 0.006), oppositional defiant disorder (odds ratio: 5.6, 95% CI: 1.139-28.128, p = 0.026), and attachment disorder (odds ratio: 4.8, 95% CI: 1.747-13.506, p = 0.004) were found significantly higher compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores, calculated by using the Early Childhood Inventory-4 form, attention deficit hyperactivity disorders severity (p= 0.006) and oppositional defiant disorder severity (p = 0.037) were found to be higher in the cow's milk allergy group. Conclusion: Psychiatric disorders are frequent and severe in pre-school children with cow's milk allergy. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.