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3D Printing of Step-Gradient Nanocomposite Hydrogels for Controlled Cell Migration

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dc.authorscopusid57194264323
dc.authorscopusid57223248935
dc.authorscopusid57197770236
dc.authorscopusid57204520867
dc.authorscopusid6602921939
dc.authorscopusid36129558600
dc.contributor.authorMotealleh, A.
dc.contributor.authorÇelebi-Saltik, B.
dc.contributor.authorErmis, N.
dc.contributor.authorNowak, S.
dc.contributor.authorKhademhosseini, A.
dc.contributor.authorKehr, N.S.
dc.date.accessioned2020-06-21T12:25:55Z
dc.date.available2020-06-21T12:25:55Z
dc.date.issued2019
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Motealleh] Andisheh, Institute of Physics, University of Münster, Munster, Nordrhein-Westfalen, Germany; [Çelebi-Saltik] Betül, Department of Stem Cell Sciences, Hacettepe Üniversitesi, Ankara, Turkey, Center for Stem Cell Research and Development, Hacettepe Üniversitesi, Ankara, Turkey; [Ermis] Nihal, Institute of Physics, University of Münster, Munster, Nordrhein-Westfalen, Germany, Department of Chemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Nowak] Sascha, University of Münster, Munster, Nordrhein-Westfalen, Germany; [Khademhosseini] Ali U., UCLA Samueli School of Engineering, Los Angeles, CA, United States, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA, United States, University of California, Los Angeles, Los Angeles, CA, United States; [Kehr] Nermin Seda, Institute of Physics, University of Münster, Munster, Nordrhein-Westfalen, Germanyen_US
dc.description.abstractIn this study, we report the step-gradient nanocomposite (NC) hydrogel generated easily by spatial connection of different nanocomposite hydrogel pastes varying in the concentrations of nanomaterials with the aid of a 3D printing technique. The prepared 3D printed gradient NC hydrogel has self-adhesive properties and is used to direct the migration of fibroblast cells towards the higher concentration of biopolymer-coated silica-based nanomaterials (NMs) within the 3D network of the hydrogel. Furthermore, we demonstrate the potential application of our gradient NC hydrogel in migration and subsequent enhanced osteogenic differentiation of human bone marrow derived mesenchymal stem cells (hBM MSC). The osteogenic differentiation of hBM MSC is achieved in the absence of osteogenic differentiation medium due to the silica-based NMs. The increase in the NM content in the gradient construct promotes hBM MSC migration and results in higher Ca2+ deposition. © 2019 IOP Publishing Ltd.en_US
dc.identifier.doi10.1088/1758-5090/ab3582
dc.identifier.issn1758-5082
dc.identifier.issn1758-5090
dc.identifier.issue4en_US
dc.identifier.pmid31344690
dc.identifier.scopus2-s2.0-85071701928
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1088/1758-5090/ab3582
dc.identifier.volume11en_US
dc.identifier.wosWOS:000482574900002
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherInstitute of Physics Publishing helen.craven@iop.orgen_US
dc.relation.ispartofBiofabricationen_US
dc.relation.journalBiofabricationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D Printingen_US
dc.subjectCell Differentiationen_US
dc.subjectCell Migrationen_US
dc.subjectGradienten_US
dc.subjectNanocomposite Hydrogelen_US
dc.title3D Printing of Step-Gradient Nanocomposite Hydrogels for Controlled Cell Migrationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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