Visualization of a Bronchial Carcinoma with Its Soft Tissue and Bone Metastasis Using Tc99m-Tetrofosmin

Abstract

Increased uptake of 1,2-bis[bis(2-ethoxyethyl) phospino]ethane (Tc-99m tetrofosmin) in tumor as well as its soft tissue and bone metastasis was demonstrated in a patient with poorly differentiated squamous cell carcinoma of the lung. 740 MBq (20 mCi) of Tc-99m tetrofosmin was injected intravenously. Following an initial dynamic acquisition of 30 minutes, static images were obtained at 30-35 and 85-90 minutes post injection (p.i.). Time to peak concentration in all three lesions was achieved within the first two minutes. Lesion to contralateral normal tissue uptake ratios of tumor, bone and soft tissue metastasis at 30-35 minutes and at 85-90 minutes p.i. were 1.62, 1.41, 3.11 and 1.43, 1.22, 1.80 respectively. We conclude that accumulation of Tc-99m tetrofosmin in tumor and metastasis at once is an encouraging finding and justifies further investigations using this agent in the domain of tumor imaging.